Polymorphism of the HLA-B*15 group of alleles is generated following 5 lineages of evolution.
作者： Jorge Martínez-Laso , Miguel Angel Herraiz , Jose Antonio Vidart , Jorge Peñaloza , Maria Luz Barbolla
DOI: 10.1016/J.HUMIMM.2011.02.013
关键词: Allele 、 Genetics 、 Intron 、 Major histocompatibility complex 、 Gene conversion 、 HLA-B 、 Biology 、 Histocompatibility 、 Polymorphism (computer science) 、 Exon
摘要: Generation of the HLA-B*15 group alleles has been analyzed using exon 1, intron 2, and 3 sequences from human nonhuman primates. Results indicated that 230 could be grouped into 5 different lineages evolution coming primate MHC-B* sharing characteristic nucleotide sequences. The major evolutionary mechanism in this is gene conversion event with exchange genomic present other HLA-B*alleles. This reflects importance exchanges between regions distinct HLA-A*, -B*, or -C* only 1 HLA-B* (B*15 paper). These data also correlated geographic distribution postulated corresponding serologic specificities (B62, -63, -71, -72, -75, -76, -77). In conclusion, high degree polymorphism a specific simple pathway evolution, which result new insight study immune system functionality, disease association studies, anthropological studies.
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