HLA-B15: A widespread and diverse family of HLA-B alleles

摘要: HLA-B15 embraces a multiplicity of antigenic specificities which vary in their distribution amongst human populations. To correlate B15 molecular structure with the serological picture we have sequenced alleles encoding various subspecificities antigen: B62, B63, B75, B76 and B77, number "variants" these antigens including 8w66 split B63. HLA-B63 (B*1517) (B*1516) heavy chains sequence identity to B17 alpha 1 helix correlating crossreactivity molecules. HLA-B77(B*1513) B75 (B*1502) differ solely segments determining Bw4 Bw6 public epitopes, consistent description B77 antigens. One allele antigen (B*1512) appears be product gene conversion between HLA-A -B loci differs from B*1501 codons 166 167. In contrast, second (B*1514) by an unrelated substitution codon 167 confers similarily B45, crossreactive B76. A third B76, B*1519, B*1512 unique point exon 4. Three variant B62 (B*1508, B*1511 B*1515) localized clusters substitutions that probably result interallelic conversion. The sequences described this paper, combination those previously determined, define family 22 alleles, B46 B70 Within patterns allelic are analogous other families, pairwise differences almost always involve functional positions recognition site recombination is major agent diversification.