A proconvulsant action of selective alpha 2-adrenoceptor antagonists.
作者： Allan Fletcher , Elaine A. Forster
DOI: 10.1016/0014-2999(88)90688-7
关键词: Convulsion 、 Pharmacology 、 Medicine 、 Internal medicine 、 Convulsants 、 Tonic (physiology) 、 Endocrinology 、 Pentylenetetrazol 、 Alpha-2 adrenergic receptor 、 Benzodiazepine 、 Seizure threshold 、 Clonidine
摘要: The effects of alpha 2-adrenoceptor agonists and antagonists were examined on seizure thresholds determined by intravenous infusions convulsants in rodents. 2-Adrenoceptor proconvulsant; dose dependently reducing the threshold for pentylenetetrazol- or bicuculline-induced tonic seizures. Strychnine-induced seizures unaffected. clonidine, BHT-933 UK 14,304 did not modify pentylenetetazol-induced at low moderate doses but high clonidine proconvulsant. facilitatory effect pentylenetetrazol-induced was blocked 14,304. proconvulsant action contrasted with that ethyl-beta-carboline-3-carboxylate, a benzodiazepine receptor contragonist, which markedly reduced initiation rather than threshold. selective blockade suggests noradrenergic mechanism is involved control propagation initiation.
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