The immune system in ultraviolet carcinogenesis.

摘要: The immune system plays an important role in ultraviolet (UV) carcinogenesis by contributing to host resistance against skin cancer development. UV radiation, however, circumvents surveillance cancers modulating the response a way that favors tumor Studies addressing cellular mechanisms which radiation modifies function are summarized. These studies demonstrate irradiation of produces both local, nonspecific suppression inhibits effector functions within irradiated skin, as well systemic, specific antigens introduced at critical time after exposure radiation. Evidence is presented suggesting production cytokines epidermal cells UV-induced DNA damage component suppression.