Silver‐Assisted Difunctionalization of Terminal Alkynes: Highly Regio‐ and Stereoselective Synthesis of Bromofluoroalkenes
作者： Yibiao Li , Xiaohang Liu , Deyun Ma , Bifu Liu , Huanfeng Jiang
关键词: Chemistry 、 Halide 、 Combinatorial chemistry 、 Reactivity (chemistry) 、 Regioselectivity 、 Silver fluoride 、 Moiety 、 Organic chemistry 、 Vinyl fluoride 、 Reagent 、 Triple bond
摘要: The difunctionalization of terminal alkynes was achieved with silver fluoride (AgF) and N-bromosuccinimide (NBS) as halogen sources. presence the halide moiety greatly enhances reactivity vinyl compounds that can probably be transformed into various products are difficult or even impossible to obtain via direct fluorination. Meanwhile, monofluoro alkenes were facilely synthesized a highly chemo- regioselective fluorination electron-deficient CC triple bonds using AgF fluorinating reagent in good yields.
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