Facile and efficient synthesis of 1-haloalkynes via DBU-mediated reaction of terminal alkynes and N-haloimides under mild conditions
作者： Mengru Li , Yueju Li , Baozhong Zhao , Fushun Liang , Long-Yi Jin
DOI: 10.1039/C4RA04736B
关键词: Organic chemistry 、 Halogen 、 Reagent 、 Chemistry
摘要: Directly from terminal alkynes and with N-halosuccinimides (halo = Br I) or N-cholorophthalimide as the halogen sources, DBU activator, 1-haloalkynes were prepared in good to excellent yields at room temperature. Bis(bromoalkyne) bis(iodoalkyne) also synthesized NBS(NIS)/DBU combination. The reaction features inexpensive readily available reagents, mild conditions, simple execution, extremely short time, broad scope, high efficiency is metal-free. Compared literature reported methods, our synthetic strategy provided a greener approach towards 1-haloalkynes.
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