Silver-Catalyzed Synthesis of 1-Chloroalkynes Directly from Terminal Alkynes
作者： Dunfa Shi , Zhiwen Liu , Ziyu Zhang , Wei Shi , Hao Chen
关键词:
摘要: An efficient method to prepare 1-chloroalkynes was investigated. The involved the use of readily available terminal alkynes and a catalytic amount silver salt with N-chlorosuccinimide as chlorinating agent under mild conditions. Compared existing process, this has broad substrate scope: 19 examples were explored, products obtained in excellent yields easily isolated by vacuum distillation. Moreover, recycling catalyst achieved simple filtration desiccation, which made more economic environmentally benign.
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