Cycloaddition-based Formal C–H Alkynylation of Isoindoles Leading to the Synthesis of Air-stable Fluorescent 1,3-Dialkynylisoindoles
作者： Toshimichi Ohmura , Akihito Kijima , Yusuke Komori , Michinori Suginome , None
DOI: 10.1021/OL401051D
关键词:
摘要: Reaction of N-alkylisoindoles with (bromoethynyl)triisopropylsilane afforded 1,3-bis(triisopropylsilylethynyl) isoindoles in high yields. The formal C–H alkynylation proceeds under transition-metal-free conditions through [4 + 2] cycloaddition the pyrrole ring isoindole bromoalkyne followed by ring-opening product.
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