Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites.

摘要: Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition strains is essential understand a wide range issues, including evolution virulence and drug resistance. In this study, we use dynamical-model based Bayesian inference investigate cause suppression an avirulent clone Plasmodium chabaudi (AS) by virulent (AJ) in immuno-deficient competent mice. We test whether caused clone-specific differences one or more following processes: adaptive immune clearance merozoites parasitised red blood cells (RBCs), background loss RBCs, RBC age preference, infection rate, burst size, within-RBC interference. These processes were parameterised dynamical mathematical models fitted experimental data. found that just parameter , ratio rate invasion mature needed be predict Interestingly, was same for both clones single-clone infections, but different mixed infections. The size difference largest immuno-competent mice smallest This explains why alleviated acts early infection, even before day peak parasitaemia. results lead us argue innate response clearing most likely, not necessarily only, mediator clones. Moreover, there interaction which induces changes strength its merozoites. What unknown, future refinement model, challenged with other datasets, may discovery.