Understanding and Predicting Strain-Specific Patterns of Pathogenesis in the Rodent Malaria Plasmodium chabaudi

摘要: Abstract: Despite considerable success elucidating important immunological and resource‐based mechanisms that control the dynamics of infection in some diseases, little is known about how differences these result strain patterns pathogenesis. Using a combination data theory, we disentangle role ecological factors (e.g., resource abundance) pathogenesis for malaria species Plasmodium chabaudi CD4+ T cell–depleted mice. We build series nested models to systematically test number potential regulatory determine “best” model using statistical techniques. The best‐fit further tested an independent set from mixed‐clone competition experiments. find parasites preferentially invade older red blood cells even when they are more fecund younger reticulocytes inoculum size has strong effect on burst reticulocytes. Importantly, results suggest strain‐specific...