Origin and Consequences of Necroinflammation.
作者： Maysa Sarhan , Walter G. Land , Wulf Tonnus , Christian P. Hugo , Andreas Linkermann
DOI: 10.1152/PHYSREV.00041.2016
关键词: Apoptosis 、 Programmed cell death 、 In vivo 、 Cell biology 、 Intracellular 、 Organelle 、 Signal transduction 、 Necrosis 、 Chemistry 、 Inflammation
摘要: When cells undergo necrotic cell death in either physiological or pathophysiological settings in vivo, they release highly immunogenic intracellular molecules and organelles into the interstitium and thereby represent the strongest known trigger of the immune system. With our increasing understanding of necrosis as a regulated and genetically determined process (RN, regulated necrosis), necrosis and necroinflammation can be pharmacologically prevented. This review discusses our current knowledge about signaling pathways of …
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