Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling.

摘要: Internalization of cell surface receptors has long been regarded as a pure means to terminate signaling via receptor degradation. A growing body information points the fact that many internalized are still in their active state and continues along endocytic pathway. Thus endocytosis orchestrates by coupling integrating different cascades on vesicles control quality, duration, intensity, distribution events. The death tumor necrosis factor-receptor 1 (TNF-R1) CD95 (Fas, APO-1) known not only signal for apoptosis but also capable inducing antiapoptotic signals transcription factor NF-κB induction or activation proliferative mitogen-activated protein kinase (MAPK)/ERK (extracellular signal-regulated kinase) cascades, resulting protection tissue regeneration. clue understanding these contradictory biological phenomena may arise from recent findings which reveal regulatory role internalization intracellular trafficking selectively transmitting signals, lead either survival cell.