Compositions and methods for dengue virus chimeric constructs in vaccines
作者： Richard M Kinney , Claire Kinney , Jill A Livengood , Dan T. Stinchcomb
DOI:
关键词: Virology 、 Biology 、 Dengue virus 、 Serotype 、 Virus 、 Dengue fever
摘要: Embodiments herein report compositions, uses and manufacturing of dengue virus constructs live attenuated viruses. Some embodiments concern a composition that includes, but is not limited to, tetravalent composition. In certain embodiments, compositions can include one or more serotypes virus, such as dengue-1 (DEN-1) dengue-2 (DEN-2) dengue-3 (DEN-3) dengue-4 (DEN-4) constructs. other disclosed be combined in to generate vaccine against may subsequently passaged mammalian cells.
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