The Pharmacological Basis of Cannabis Therapy for Epilepsy

摘要: Recently, cannabis has been suggested as a potential alternative therapy for refractory epilepsy, which affects 30% of both adults and children, who do not respond to current medications. There is large unmet medical need new antiepileptics that would interfere with normal function in patients epilepsy conditions associated seizures. The two chief cannabinoids are Δ-9-tetrahyrdrocannabinol, the major psychoactive component marijuana, cannabidiol (CBD), nonpsychoactive marijuana. Claims clinical efficacy CBD-predominant or marijuana come mostly from limited studies, surveys, case reports. However, mechanisms underlying antiepileptic remain unclear. This article highlights pharmacological basis therapy, an emphasis on endocannabinoid emerging neurotherapeutics CBD epilepsy. anticonvulsant, but it low affinity cannabinoid receptors CB1 CB2; therefore exact mechanism by seizures remains poorly understood. A rigorous evaluation pharmaceutical products needed establish safety their use treatment Identification anticonvulsant also critical identifying other options.