Spicing Up Pharmacology: A Review of Synthetic Cannabinoids From Structure to Adverse Events

摘要: Recreational use of synthetic cannabinoids (SCB), a class novel psychoactive substances is an increasing public health problem specifically in Western societies, with teenagers, young adults, and the prison population being most affected. Some these SCB are analogs tetrahydrocannabinol, aminoalkylindoles, other phytocannabinoid have been detected herbal preparations generically called "Spice." Spice, "K2" or "fake cannabis" general term used for variable mixtures unknown ingredients chemical composition. highly potent CB1 cannabinoid receptor agonists falsely marketed sold as safe legal drugs. Here, we present overview endocannabinoid system, CB, structures activity at CB receptors. Finally, highlight psychological effects SCB, particularly on learning memory, adverse clinical including cardiovascular kidneys, CNS, psychosis. Taken together, it clear that many extremely dangerous major problem.