Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106.
作者： Akihiro Takano , Ryosuke Arakawa , Hiroshi Ito , Amane Tateno , Hidehiko Takahashi
DOI: 10.1017/S1461145710000313
关键词: Positive and Negative Syndrome Scale 、 GABAA receptor 、 Pathology 、 Peripheral 、 Microglia 、 Pathophysiology 、 Chronic schizophrenia 、 Positron emission tomography 、 Schizophrenia 、 Psychology
摘要: Inflammatory/immunological process and glial contribution are suggested in the pathophysiology of schizophrenia. We investigated peripheral benzodiazepine receptors brains patients with chronic schizophrenia, which were reported to be located on mitochondria cells, using [11C]DAA1106 positron emission tomography. Fourteen 14 age- sex-matched normal controls participated this study. PET data analysed by two-tissue compartment model metabolite-corrected plasma input. Clinical symptoms assessed Positive Negative Syndrome Scale. There was no significant difference between binding cortical regions whereas showed a positive correlation symptom scores. also duration illness. Although correlations need interpreted very cautiously, involvement reaction or progressive change schizophrenia might suggested.
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