Synchrony of telomere length among hematopoietic cells

摘要: Objective Little is known about the relationship of telomere length among leukocyte subsets and cells up hematopoietic hierarchy. This information relevant because dynamics in granulocytes were postulated to mirror those stem (HSCs). Materials Methods In newborn umbilical cord blood (UCB), we examined relationships progenitor (HPCs) (CD34 + CD45 − ) with T lymphocytes granulocytes. addition, correlated whole samples individuals ranging age from birth 100 years. Results UCB, found strong correlations HPCs ( r 0.882 0.935; p 0.0038 0.0007) = 0.930; 0.0072). At birth, also observed between all leukocytes 0.979; 0.0003). Throughout human lifespan, that was > 0.980 Conclusions Robust synchrony exists throughout lifespan; relatively long (or short) telomeres one subset have other subsets. Moreover, reflects its hierarchy, i.e., and, by inference, HSCs. Strong links been many studies a host aging-related diseases. Our findings suggest, therefore, these might be traced