Use of elevated bone turnover to predict bone metastasis

摘要: 591 Background: A favorable “soil” has been suggested as an important factor for the growth of cancer cells. In this study, ability pretreatment serum beta C-terminal telopeptide (B-CTx) type I collagen, a marker bone resorption, to predict breast relapse in was investigated randomized adjuvant trial. Methods: Serum B-CTx concentration (Serum CrossLaps, Nordic Biosciences, Copenhagen, DN) determined from 621 667 primary patients enrolled NCIC CTG MA.14 phase III clinical trial tamoxifen (20 mg po daily, 323 pts.) ± octreotide (90 mo. 2 years, 298 which recently had its final analysis. Stratification by administration chemotherapy, axillary lymph node status, and ER and/or PR status. Recurrence-free survival (RFS) secondary endpoint defined time randomization recurrence disease alone; focus here bone-only recurrenc...