Randomized feasibility study of de-escalated (every 12 wk) versus standard (every 3 to 4 wk) intravenous pamidronate in women with low-risk bone metastases from breast cancer.
作者： Eitan Amir , Orit Freedman , Lindsay Carlsson , George Dranitsaris , George Tomlinson
DOI: 10.1097/COC.0B013E3182568F7A
关键词: Dosing interval 、 Individual risk 、 Bone disease 、 Randomized controlled trial 、 Breast cancer 、 Surgery 、 Medicine 、 Internal medicine 、 Bisphosphonate
摘要: Objectives:Despite substantial variability in individual risk of skeletal complications, patients with metastatic bone disease are treated bisphosphonates at the same dose and dosing interval. This study assessed feasibility conducting a randomized trial less frequent bisphosphonate
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