NMDA receptor permeation: a light in the tunnel
作者： David J A Wyllie , Stephen F Traynelis
DOI: 10.1038/NN.3058
关键词: Ion channel 、 NMDA receptor 、 Conductance 、 Residue (chemistry) 、 Permeation 、 Key features 、 AMPA receptor 、 Single amino acid 、 Chemistry 、 Biophysics 、 Neuroscience
摘要: A single amino acid residue determines single-channel conductance, ion permeation and channel block in the NMDA receptor, three of key features this ligand-gated channel.
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Thomas Kuner, Ralf Schoepfer, Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels The Journal of Neuroscience. ,vol. 16, pp. 3549- 3558 ,(1996) , 10.1523/JNEUROSCI.16-11-03549.1996
J R Howe, S G Cull-Candy, D Colquhoun, Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells. The Journal of Physiology. ,vol. 432, pp. 143- 202 ,(1991) , 10.1113/JPHYSIOL.1991.SP018381
Ralf Schneggenburger, Philippe Ascher, Coupling of Permeation and Gating in an NMDA-Channel Pore Mutant Neuron. ,vol. 18, pp. 167- 177 ,(1997) , 10.1016/S0896-6273(01)80055-6
Stuart G. Cull-Candy, Maria M. Usowicz, Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons. Nature. ,vol. 325, pp. 525- 528 ,(1987) , 10.1038/325525A0
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz, Magnesium gates glutamate-activated channels in mouse central neurones Nature. ,vol. 307, pp. 462- 465 ,(1984) , 10.1038/307462A0
Mark L. Mayer, Gary L. Westbrook, Peter B. Guthrie, Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature. ,vol. 309, pp. 261- 263 ,(1984) , 10.1038/309261A0
Alexander I. Sobolevsky, Michael P. Rosconi, Eric Gouaux, X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor Nature. ,vol. 462, pp. 745- 756 ,(2009) , 10.1038/NATURE08624
Kevin K. Ogden, Stephen F. Traynelis, New advances in NMDA receptor pharmacology. Trends in Pharmacological Sciences. ,vol. 32, pp. 726- 733 ,(2011) , 10.1016/J.TIPS.2011.08.003
Beth Siegler Retchless, Wei Gao, Jon W Johnson, A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction Nature Neuroscience. ,vol. 15, pp. 406- 413 ,(2012) , 10.1038/NN.3025
Keiko Kashiwagi, Takashi Masuko, Christopher D. Nguyen, Tomoko Kuno, Ikuko Tanaka, Kazuei Igarashi, Keith Williams, Channel Blockers Acting atN-Methyl-d-aspartate Receptors: Differential Effects of Mutations in the Vestibule and Ion Channel Pore Molecular Pharmacology. ,vol. 61, pp. 533- 545 ,(2002) , 10.1124/MOL.61.3.533