Transcription-Coupled DNA Repair Overview
作者： S. Tornaletti
DOI: 10.1016/B978-0-12-378630-2.00280-2
关键词: Genetics 、 Biology 、 DNA damage 、 Nucleotide excision repair 、 DNA mismatch repair 、 DNA repair 、 DNA polymerase 、 Replication protein A 、 DNA polymerase II 、 DNA repair protein XRCC4
摘要: Maintenance of genome integrity is essential for normal cellular function. However, cells are continually exposed to DNA damage caused by a multitude endogenous and environmental sources. Persistence in the cell may generate deleterious mutations genetic material that cause deregulation gene expression result human disease cancer. As result, several dedicated repair pathways have evolved all organisms remove lesions from genome. A unique problem arises when located transcribed regions Some pause elongation process while others represent absolute blocks translocation RNA polymerase. Arrest transcription at sites represents strong signal apoptosis. To prevent accumulation complexes arrested damage, specialized nucleotide excision pathway called ‘transcription-coupled repair’, removal blocking strands expressed genes.
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