Melanocortin receptor-3 ligands to treat sexual dysfunction
作者： Beverly E. Girten , Sandra R. Slivka , Ronald R. Tuttle , Hengyuan Lang , Douglas L. Hitchin
DOI:
关键词: Melanocortin 、 Melanocortin 3 receptor 、 Erectile dysfunction 、 Internal medicine 、 Psychology 、 Sexual arousal disorder 、 Antagonist 、 Melanocortin 4 receptor 、 Agonist 、 Sexual dysfunction 、 Endocrinology
摘要: Methods for treating sexual dysfunction, such as erectile dysfunction or arousal disorder, with a compound having the generic formula X1—X2-(D)Phe-Arg-(D)Trp-X3. A particularly useful is HP-228, which has Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH2. The invention also provides methods selecting melanocortin receptor-3 ligands by determining whether modulates activity of MC-3 an agonist antagonist. These can be used to screen libraries treat MC-3-associated conditions. Such conditions include including and disorder.
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