Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals

摘要: The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and cells into which said have been introduced that express functional receptors. a panel of such transformed expressing receptors for screening compounds receptor agonist antagonist activity. also methods using panels receptor-expressing to specifically detect identify agonists antagonists each receptor, as well patterns activity the class Such provide means identifying with is associated capacity influence or modify metabolism behavior, particularly feeding behavior.