Intravenous Lidocaine for Neuropathic Pain: A Retrospective Analysis of Tolerability and Efficacy
作者： Paul Hutson , Miroslav Backonja , Hanna Knurr
DOI: 10.1111/PME.12642
关键词: Toxicity 、 Side effect 、 Adverse effect 、 Medicine 、 Intravenous lidocaine 、 Neuropathic pain 、 Analgesic 、 Anesthesia 、 Lidocaine 、 Tolerability
摘要: Objectives This study was designed to describe the efficacy and toxicity of intravenous (i.v.) lidocaine infusions for treatment neuropathic pain initially administered at a flat-rate trial dose 500 mg over 30 minutes. Setting Academic, tertiary care hospital infusion center. Methods Data were retrospectively collected analyzed efficacy, correlations between rates with adverse effects, patterns rate adjustments, frequencies. Results The average all 9.1 mg/min. Efficacy seen in 45 patients (65%), but eight (12%) required reductions from initial test 16.7 mg/min due effects. Fifty-five experienced light-headedness as most frequently reported side effect. Conclusion flat-dose used under University Wisconsin Health protocol i.v. administration did not cause serious events, few who responded this tolerated subsequent rate. Due lack administering an aggressive elicit analgesic response appears be rational. If show benefit dose, need doses should anticipated.
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