Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury
作者： Ryuji Terayama , Naoko Fujisawa , Daisuke Yamaguchi , Shinji Omura , Hiroyuki Ichikawa
DOI: 10.1016/J.NEURES.2010.11.004
关键词: Kinase 、 Microglia 、 Biology 、 Pathology 、 p38 mitogen-activated protein kinases 、 Astrocyte 、 Trigeminal nerve 、 MAPK/ERK pathway 、 NeuN 、 Nerve injury
摘要: Mitogen-activated protein kinases (MAPKs) play a pivotal role in the mediation of cellular responses to variety signaling molecules. The current study demonstrates phosphorylation extracellular signal-regulated kinase (ERK) and p38 MAPK each subdivision trigeminal sensory nuclear complex (TSNC) following lingual nerve injury. Immunohistochemical labeling for phosphorylated ERK (p-ERK) or (p-p38) was performed histological sections brainstem. A transient increase immunoreactivity p-ERK found TSNC followed by prolonged p-p38 after Double immunofluorescence with cell-specific markers revealed that were predominantly OX-42-positive microglia GFAP-positive astrocytes. Increased OX-42 GFAP indicated astrocytes activated injury TSNC. Activation MAPKs glial cells rostral subdivisions comparable subnucleus caudalis spinal tract nucleus (Vc). We conclude differential activation as well Vc may have substantial pathogenesis neuropathic pain
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