作者: O. V. Krasilnikov
DOI: 10.1007/978-94-010-0401-5_6
关键词: Ethylene glycol 、 Nanometre 、 Chemical engineering 、 Conductivity 、 Materials science 、 Ionic bonding 、 Polymer 、 Ion channel 、 PEG ratio 、 Conductance
摘要: We have developed a method for determining the physical dimensions of nanometer scale pores formed by protein ion channels. This was possible because availability wide range size-selected nonelectrolyte polymers poly(ethylene glycol), PEG, and PEG decreases bulk conductivity ionic solutions. The is simple. PEGs that are sufficiently small enter channel’s pore decrease conductance. larger than pore’s diameter rarely partition into therefore do not channel Thus, dependence conductance on molecular weight determines cut-off, inference, radius. recently extended technique to determine shape lumen including sizes both openings size location constrictions inside pore. discuss here details method, properties some limitations using size.