The non-muscle myosin phosphatase PP1β (flapwing) negatively regulates JNK in wing imaginal discs of Drosophila

作者： Luke Alphey , Sascha Gross , Jasmin Kirchner , Daimark Bennett

DOI:

关键词: Myosin 、 Cell biology 、 Imaginal disc 、 Phosphorylation 、 Chemistry 、 Mutant 、 Threonine 、 Kinase 、 Phosphatase 、 Anatomy 、 Serine

摘要: Drosophila flapwing (flw) codes for serine/threonine protein phosphatase type 1β (PP1β). Regulation of non-muscle myosin activity is the single essential flw function that nonredundant with three closely related PP1α genes. Flw thought to dephosphorylate nonmuscle regulatory light chain, Spaghetti Squash (Sqh); this inactivates heavy Zipper (Zip). Thus, strong mutants lead hyperphosphorylation Sqh and hyperactivation activity. Here, we show genetically a Jun Nterminal kinase (JNK) mutant suppresses semi-lethality allele. Alleles JNK puckered (puc) enhance weak allele flw, leading severe wing defects. Introducing binding subunit (Mbs) further enhances genetic interaction lethality. We puc expression upregulated in imaginal discs puc, upregulation modified by Zip. The level phosphorylated (active) elevated enhanced puc. Together, disruption activates

暂无可下载资源，当前可以选择系统获取到有开放资源时通知我或者直接发起求助文献求助

参考文章(44)

M Nishikawa, J R Sellers, R S Adelstein, H Hidaka, Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase. Journal of Biological Chemistry. ,vol. 259, pp. 8808- 8814 ,(1984) , 10.1016/S0021-9258(17)47225-5

Takashi Adachi-Yamada, Konomi Fujimura-Kamada, Yasuyoshi Nishida, Kunihiro Matsumoto, Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature. ,vol. 400, pp. 166- 169 ,(1999) , 10.1038/22112

B G Leicht, J J Bonner, Genetic analysis of chromosomal region 67A-D of Drosophila melanogaster. Genetics. ,vol. 119, pp. 579- 593 ,(1988) , 10.1093/GENETICS/119.3.579

Takashi Adachi-Yamada, Tomokazu Gotoh, Isamu Sugimura, Minoru Tateno, Yasuyoshi Nishida, Tomoya Onuki, Hideyuki Date, De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Molecular and Cellular Biology. ,vol. 19, pp. 7276- 7286 ,(1999) , 10.1128/MCB.19.10.7276

Daniel P. Kiehart, Susan R. Halsell, Cynthia A. Bayer, Laurence von Kalm, James W. Fristrom, Genetic Interactions Between the RhoA and Stubble-stubbloid Loci Suggest a Role for a Type II Transmembrane Serine Protease in Intracellular Signaling During Drosophila Imaginal Disc Morphogenesis Genetics. ,vol. 165, pp. 1417- 1432 ,(2003) , 10.1093/GENETICS/165.3.1417

Benoit Dérijard, Masahiko Hibi, I-Huan Wu, Tamera Barrett, Bing Su, Tiliang Deng, Michael Karin, Roger J. Davis, JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell. ,vol. 76, pp. 1025- 1037 ,(1994) , 10.1016/0092-8674(94)90380-8

Takashi Adachi-Yamada, Michael B O’Connor, Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis. Journal of Biochemistry. ,vol. 136, pp. 13- 17 ,(2004) , 10.1093/JB/MVH099

Bruno Glise, Henri Bourbon, Stéphane Noselli, HEMIPTEROUS ENCODES A NOVEL DROSOPHILA MAP KINASE KINASE, REQUIRED FOR EPITHELIAL CELL SHEET MOVEMENT Cell. ,vol. 83, pp. 451- 461 ,(1995) , 10.1016/0092-8674(95)90123-X

Heinrich Jasper, Vladimir Benes, Christian Schwager, Silvia Sauer, Sandra Clauder-Münster, Wilhelm Ansorge, Dirk Bohmann, The Genomic Response of the Drosophila Embryo to JNK Signaling Developmental Cell. ,vol. 1, pp. 579- 586 ,(2001) , 10.1016/S1534-5807(01)00045-4

10.

Jeffery Yong, Ivan Tan, Louis Lim, Thomas Leung, Phosphorylation of Myosin Phosphatase Targeting Subunit 3 (MYPT3) and Regulation of Protein Phosphatase 1 by Protein Kinase A Journal of Biological Chemistry. ,vol. 281, pp. 31202- 31211 ,(2006) , 10.1074/JBC.M607287200

The non-muscle myosin phosphatase PP1β (flapwing) negatively regulates JNK in wing imaginal discs of Drosophila

来源期刊

我的账户

The non-muscle myosin phosphatase PP1β (flapwing) negatively regulates JNK in wing imaginal discs of Drosophila

来源期刊

相似文章 0

我的账户