Genetic Interactions Between the RhoA and Stubble-stubbloid Loci Suggest a Role for a Type II Transmembrane Serine Protease in Intracellular Signaling During Drosophila Imaginal Disc Morphogenesis

摘要: The Drosophila RhoA (Rho1) GTPase is essential for postembryonic morphogenesis of leg and wing imaginal discs. Mutations in enhance defects associated with mutations zipper, the gene encoding heavy chain nonmuscle myosin II. We demonstrate here that affecting signaling pathway also interact genetically Stubble-stubbloid (Sb-sbd) locus encodes an unusual type II transmembrane serine protease required normal morphogenesis. In addition, a malformation phenotype overexpression Sb-sbd prepupal discs suppressed when dose reduced, suggesting act common during characterized six identified as enhancers zipper mutant defects. Three these genes encode known members (RhoA, DRhoGEF2, zipper). remaining three enhancer both mutations, they additional components Our results provide evidence proteases, class proteins linked to human developmental abnormalities pathology, may be intracellular development.