Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment.

摘要: Mice deficient in lymphotoxin (LT)-alpha lack peripheral lymph nodes and Peyer's patches have profound defects development of follicular dendritic cell networks, germinal center formation, T/B segregation the spleen. Although LTalpha is known to be expressed by NK cells as well T B lymphocytes, requirement for functions largely unknown. To address this issue, we assessed LTalpha-deficient mice evaluating tumor models with requirements control their growth metastasis. Syngeneic B16F10 melanoma inoculated s.c. grew more rapidly LTalpha-/- than wild-type littermates, formation experimental pulmonary metastases was significantly enhanced mice. exhibited almost a normal total number spleen, they showed an impaired recruitment lung liver. Additionally, lytic were not efficiently produced from bone marrow vitro presence IL-2 IL-15. These data suggest that signaling may involved maturation play important role antitumor surveillance.