Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
作者： D Kagi , F Vignaux , B Ledermann , K Burki , V Depraetere
关键词: Ionomycin 、 Cell biology 、 T lymphocyte 、 Fas receptor 、 Antigen 、 Biology 、 Effector 、 Perforin 、 T cell mediated cytotoxicity 、 Cytotoxicity 、 Immunology
摘要: Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine extent their contribution to a range effector cells from normal control or perforin-deficient mice were tested against panel target with various levels Fas expression. All cytotoxicity observed was due either these mechanisms, and no third mechanism detected. Thus, perforin- Fas-based may account for all in short-term vitro assays.
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Svante Pääbo, K. Kärre, H.G. Ljunggren, P. Kourilsky, G. Kling, M. Cochet, Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis. Journal of Immunology. ,vol. 142, pp. 2911- 2917 ,(1989)
Peter Perlmann, Göran Holm, Cytotoxic effects of lymphoid cells in vitro. Advances in Immunology. ,vol. 11, pp. 117- 193 ,(1969) , 10.1016/S0065-2776(08)60479-4
B. Trauth, C Klas, A. Peters, S Matzku, P Moller, W Falk, K. Debatin, P. Krammer, Monoclonal antibody-mediated tumor regression by induction of apoptosis Science. ,vol. 245, pp. 301- 305 ,(1989) , 10.1126/SCIENCE.2787530
P C Doherty, W E Biddison, J R Bennink, B B Knowles, Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. Journal of Experimental Medicine. ,vol. 148, pp. 534- 543 ,(1978) , 10.1084/JEM.148.2.534
Françoise Vignaux, Pierre Golstein, Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway? European Journal of Immunology. ,vol. 24, pp. 923- 927 ,(1994) , 10.1002/EJI.1830240421
S Yonehara, A Ishii, M Yonehara, A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor Journal of Experimental Medicine. ,vol. 169, pp. 1747- 1756 ,(1989) , 10.1084/JEM.169.5.1747
E Rouvier, M F Luciani, P Golstein, Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. Journal of Experimental Medicine. ,vol. 177, pp. 195- 200 ,(1993) , 10.1084/JEM.177.1.195
Andreas Conzelmann, Patricia Corthésy, Maurizio Cianfriglia, Augusto Silva, Markus Nabholz, Hybrids between rat lymphoma and mouse t cells with inducible cytolytic activity. Nature. ,vol. 298, pp. 170- 172 ,(1982) , 10.1038/298170A0
Rie Watanabe-Fukunaga, Camilynn I. Brannan, Neal G. Copeland, Nancy A. Jenkins, Shigekazu Nagata, Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Nature. ,vol. 356, pp. 314- 317 ,(1992) , 10.1038/356314A0
John W. Shiver, Lishan Su, Pierre A. Henkart, Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A. Cell. ,vol. 71, pp. 315- 322 ,(1992) , 10.1016/0092-8674(92)90359-K