The prognostic role of lymphovascular invasion in urothelial carcinoma of the bladder

作者: Romain Mathieu , Ilaria Lucca , Morgan Rouprêt , Alberto Briganti , Shahrokh F. Shariat

DOI: 10.1038/NRUROL.2016.126

关键词: ConcordanceUrinary bladderOncologyMetastasisMedicineUrologyCystectomyLymphovascular invasionBiopsyBladder cancerInternal medicineNomogram

摘要: Outcome prediction in patients with bladder cancer has improved through the development of nomograms and predictive models. However, integration further characteristics such as lymphovascular invasion (LVI) might increase accuracy clinical utility these instruments. Assessment reporting LVI specimens from transurethral resection tumour (TURBT) or biopsy non-muscle-invasive (NMIBC) muscle-invasive (MIBC) enable staging, prognostication decision-making. In NMIBC, presence TURBT samples seems to be associated understaging increased risks disease recurrence progression. MIBC, is features aggressive predicts survival. Integration status into models aid decision-making regarding intravesical instillation schedules regimens, early radical cystectomy high-grade T1 perioperative chemotherapy. assessment hampered by insufficient reproducibility reliability, lack routine evaluation limited concordance between findings specimens. Standardization pathological criteria defining warranted improve its practice a care-changing prognostic marker.

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