Effect of Hypervolemic Therapy on Cerebral Blood Flow After Subarachnoid Hemorrhage A Randomized Controlled Trial

摘要: Background and Purpose—Cerebral blood flow (CBF) is reduced after subarachnoid hemorrhage (SAH), symptomatic vasospasm a major cause of morbidity mortality. Volume expansion has been reported to increase CBF SAH, but values in hypervolemic (HV) normovolemic (NV) subjects have never directly compared. Methods—On the day aneurysm clipping, we randomly assigned 82 patients receive HV or NV fluid management until SAH 14. In addition 80 mL/h isotonic crystalloid, 250 mL 5% albumin solution was given every 2 hours maintain normal (NV group, n=41) elevated (HV cardiac filling pressures. (133xenon clearance) measured before randomization approximately 3 days thereafter (mean, 4.5 studies per patient). Results—HV received significantly more had higher pulmonary artery diastolic central venous pressures than patients, there no effect on net balance volume third...