Neuropsychological performance in OCD: a study in medication-naïve patients.

摘要: Abstract Background Obsessive–compulsive disorder (OCD) is associated with impairments in multiple neuropsychological domains but the findings are rather inconsistent across studies. One potential reason for poor replication confounding influence of medications. There limited research on performance medication-naive, never treated OCD patients. Methods In this study, we assessed 31 never-treated, DSM-IV patients free comorbid major depression and healthy controls individually matched age, gender years education, tests attention, executive function, memory reasoning visuo-spatial function. Results Medication-naive did not significantly differ from most tests. Patients performed somewhat poorly only highest goal hierarchy Tower London (TOL) test (p = 0.001, effect size = 0.68). Conclusions It intriguing to find that symptomatic, drug-naive Our finding medium size TOL suggests brain regions outside affective orbitofrontal loop may also be perhaps involved OCD. This however needs because modest size. Future studies should focus studying co-morbidity-free relatives using symptom dimensions consistent robust findings.