The role of arginine vasopressin in diabetes-associated increase in glucagon secretion.
作者： Sirintorn Yibchok-anun , Ehab A. Abu-Basha , Cheng-Yu Yao , Wara Panichkriangkrai , Walter H. Hsu
DOI: 10.1016/J.REGPEP.2004.06.010
关键词: Diabetes mellitus 、 Streptozotocin 、 Glucagon 、 Glucagon secretion 、 Internal medicine 、 Vasopressin 、 Pancreas 、 Insulin 、 Endocrinology 、 Pancreatic hormone 、 Medicine
摘要: Abstract The purpose of this study was to investigate the role arginine vasopressin (AVP) on glucagon secretion in both normal and diabetic rats. Diabetes induced by intravenous administration 50 mg/kg streptozotocin, 14 days before pancreatic perfusion. Diabetic rats were maintained insulin replacement therapy until ∼48 h perfusion experiments. Both AVP determined effluent perfused pancreas using RIA. had similar basal secretion. (3–30 pM) increased from a concentration-dependent manner. However, subjects more sensitive than with regard By comparison areas under curves, AVP-induced ∼2-fold that In addition, immunoreactive detected pancreas, 70% higher concentrations We conclude is secreted can secrete Consequently, may have greater impact ones. might play an important hypersecretion subjects.
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