Modulation of insulin and glucagon secretion from the perfused rat pancreas by the neurohypophysial hormones and by desamino-D-arginine vasopressin (DDAVP)
作者： B.E. Dunning , J.H. Moltz , C.P. Fawcett
DOI: 10.1016/0196-9781(84)90109-8
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摘要: Marked stimulation of glucagon release and modest insulin were observed during in situ perfusion the rat pancreas with AVP or OT. Glucagon response to OT (200 pg/ml) gradually increased over a 45 min period reaching maxima 500% 300% pre-stimulatory levels, respectively. Insulin transiently by 100%. In each case rates returned control values immediately after withdrawal peptides. Total was concentration dependent linear from 20 pg ng OT/ml (r>.97). Pancreatic DDAVP perfused at ng/ml virtually indistinguishable that induced 200 pg/ml. This demonstration glucagonotrophic action neurohypophysial hormones confirms earlier studies using isolated islets bolus IV injection.
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