Glucose homeostasis and hypothalamic-pituitary-adrenocortical axis during development in rats.

摘要: Glucoprivation represents a model stress in which activation of different responses at ages can be monitored both vivo and vitro. Physiological data indicate rat brain contains liver/pancreas-type glucose sensor, yet no biochemical or immunocytochemical evidence exists for such sensor. Young rats appear to lack normal hypothalamic glucose-sensing ability do not show typical secretory patterns corticotropin-releasing factor, adrenocorticotropic hormone, corticosterone after experimentally induced glucoprivation. However, they hypersecrete catecholamines glucagon (compared with adults) thrive on fuel sources other than that are abundant birth. High steroid levels during the first 24 h birth may critical inducing gluconeogenic enzymes promoting differentiation tissues like pancreas. Neonatal also have unique control systems combat damaging effects stresses hypoxia; these disappear adults. Thus definition change development, compensatory mechanisms employed from neonatal adult life intricately related metabolic needs animal.