The induction of abortion by prostaglandin F2α

摘要: D u R I N G EC E T years, prostaglandin F,, and E, have been found to a potent stimulating effect on the pregnant uterus. We already reported our experience in using PGF,, for induction of labor comparison its with that oxytocin terms uterine contractions.1 Now possibility Fza (PGF& termination early middle pregnancy has investigated department. Intravenous infusions were given 15 women admitted therapeutic abortion, missed or prematurely ruptured membranes sixth twenty-ninth weeks pregnancy. Uterine contractility was measured by recording changes intrauterine pressure from an open-end catheter microballoon cathger introduced into cavity through cervix. The dose levels increased stepwise individual patients until effective contractions produced. With intravenous infusion 41 55 pg per minute used this study, stimulation activity observed 7 stages (from fourteenth gestation) (Fig. 1). response which appeared after latent period 10 20 minutes characterized increase tone varied between 30 mm. Hg. In these cases appearing succession superimposed hypertonus. These gradually became stronger 40 Hg amplitude 50 seconds short interval. uterus began contract regularly rhythmically 120 200 start infusion, amplitude, 60 duration, 90 interval contractions, lasted continuing infusions. Infusion time ranged 6 hours 16 36 minutes. all bleeding occurred several but did not abnormally amount. 3 out cases, fetus placenta completely expelled simultaneously. Patient during postpartum amenorrhea, size her corresponded 17 over days failed dilate more than 1 cm. cervix despite strong throughout period. Due failure dilating metreurynter ml. sterile saline pulled 300 g traction load. dilated 2.5 5 hours. Under cervical condition, caused abortion twin followed. actual maturity estimated be thirteenth There various kinds side effects, none serious. most common diarrhea seen patients. Nausea, vomiting, hypogastric pain, headache, cough, flushing, phlebitis some them transient usually responded symptomatic treatment. 2 suffered remarkable epigastralgia, diarrhea, disappeared when stopped, restarted same symptoms refractory 11 33 rate smaller amount one 8 mid-pregnancy eighteenth pregnancy). advanced pregnancy,