Early postoperative changes in hematological, erythrocyte aggregation and blood coagulation parameters after unilateral implantation of polytetrafluoroethylene vascular graft in the femoral artery of beagle dogs
作者： Csaba Toth , Zoltan Klarik , Ferenc Kiss , Eniko Toth , Zoltan Hargitai
DOI: 10.1590/S0102-86502014000500006
关键词: Partial thromboplastin time 、 Anesthesia 、 Blood sampling 、 Surgery 、 Platelet 、 Thrombus 、 Fibrinogen 、 Thrombosis 、 Medicine 、 Femoral artery 、 Erythrocyte aggregation
摘要: PURPOSE: The failure of small-caliber vascular grafts still means a serious problem. Concerning the early postoperative complications we aimed to investigate hemostaseological and hemorheological aspects this issue in canine model.METHODS: In Control group only anesthesia was induced. Grafted under general 3.5-cm segment resected unilaterally from femoral artery replaced with PTFE graft (diameter: 3 mm). On 1st-3rd-5th-7th 14thpostoperative days skin temperature both hind limbs measured, blood sampling occurred for hematological, tests.RESULTS: operated versus intact did not differ. leukocyte count elevated by 1st day, while platelet increased over entire follow-up period. Fibrinogen concentration rose on 1st-5th days, activated partial thromboplastin time 3rd-7th days. Erythrocyte aggregation enhanced significantly specimens taken 14thday, histologically found matured thrombus narrowing lumen.CONCLUSIONS:Small-caliber implantation into caused significant changes several parameters. However, better clarifying factors leading thrombosis these needs further studies.
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