Hemorheological changes in ischemia-reperfusion: an overview on our experimental surgical data.

摘要: Blood vessel occlusions of various origin, depending on the duration and extension, result in tissue damage, causing ischemic or ischemia-reperfusion injuries. Necessary surgical clamping vessels vascular-, gastrointestinal parenchymal organ surgery, flap preparation-transplantation reconstructive as well traumatological vascular occlusions, all present special aspects. Ischemia reperfusion have effects hemorheological state by numerous ways: besides local metabolic micro-environmental changes, hemodynamic alterations, free-radical inflammatory pathways, acute phase reactions coagulation changes. These processes may be harmful for red blood cells, impairing their deformability influencing aggregation behavior. However, there are still many unsolved non-completely answered questions relation hemorheology ischemia-reperfusion. How do (liver, kidney, small intestine) limb ischemic-reperfusionic different temperature affect factors? What is expected magnitude dynamics these alterations? Where border irreversibility? can investigations applied to experimental models using laboratory animals respect inter-species differences? This paper gives a summary some our research data organ/tissue ischemia-reperfusion, microcirculation, related microsurgery.