3,5,4'-Tri-O-acetylresveratrol decreases seawater inhalation-induced acute lung injury by interfering with the NF-κB and i-NOS pathways.

作者: LIJIE MA , XIANGJUN CHEN , RUIXUAN WANG , HONGTAO DUAN , LIBIN WANG

DOI: 10.3892/IJMM.2015.2403

关键词: Bronchoalveolar lavageInhalationLung injuryIn vivoEvans BlueBiologyNitric oxidePathologyPharmacologyArtificial seawaterLung

摘要: Drowning is a cause of accidental mortality. However, survival may result in acute lung injury. The aim the present study was to evaluate effects 3,5,4'-tri-O-acetylresveratrol (AC-Res) on injury (ALI) induced by seawater inhalation rats. ALI models were established tracheal instillation artificial with or without 50 mg/kg AC-Res pretreatment for 7 days. Lung samples from different groups harvested 4 h after model established. Histological changes, blood vessel permeability, inflammatory factor secretion and expression states nuclear factor-κB (NF-κB) inducible NOS (i-NOS) pathway assessed seawater‑induced protective acetylated resveratrol. results showed that inspiration led physiological structure changes an increased permeability vessels. In addition, stimulation enhanced levels nitric oxide (NO), tumor necrosis α (TNF-α) interleukin-1 β (IL-1β) vitro vivo. Notably, NF-κB i-NOS lungs cells. On other hand, inhibited abnormal pathways, followed decreased NO, TNF-α IL-1β secretion, protein cell content bronchoalveolar lavage fluid (BALF) Evans blue, infiltration vessels into tissues. therefore suggest attenuated induced‑ALI interfering pathways.

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