Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin.

摘要: Proximal duodenal bicarbonate secretion is an important factor in humans and animals protecting the mucosa against acid-peptic damage. This study examined mechanisms responsible for central nervous system regulation of by calcitonin gene-related peptide (CGRP) unrestrained rats. Cerebroventricular administration rat CGRP significantly inhibited basal as well stimulatory effects vasoactive intestinal peptide, neurotensin, a luminal PGE1 analogue, misoprostol, hydrochloric acid. The inhibitory cerebroventricular were abolished ganglionic blockade with chlorisondamine, attenuated noradrenergic bretylium, enhanced vagotomy. Inhibition induced coincided significant increases plasma norepinephrine (NE) vasopressin concentrations. alpha adrenergic receptor antagonist, phentolamine, V1 (1-deaminopenicillamine, 2-[O-methyl]Tyr, 8-Arg)-vasopressin, given intravenously reversed effect approximately 50% each. Pretreatment both phentolamine antagonist completely CGRP. Peripheral NE decreased secretion, their additive prevented respectively. We conclude that inhibits activation sympathetic efferents subsequent release act on receptors,