Review article: gastroduodenal bicarbonate secretion.

摘要: SUMMARY The gastroduodenal epithelium is covered by an adherent mucus layer into which bicarbonate secreted surface epithelial cells. This mucus-bicarbonate barrier important first line of defence against damage gastric acid and pepsin, has been demonstrated in all species including human. Similar to secretion, regulation duodenal secretion can be divided three phases: cephalic, duodenal. In humans, sham-feeding increases both the stomach duodenum mediated cholinergic vagal fibres stomach, but seems noncholinergic duodenum. Gastric distention luminal acidification production. Whereas there are no data relating phase human animals, food independently stimulate output. To date, not studied, from animals reveal that augments stomach. tested, direct a potent stimulant local pH threshold for 3.0. Mediation provided variety agonists antagonists, tested mainly some have evaluated humans. Prostaglandins E class VIP major factors control secretion. Bicarbonate general, adversely effected ulcerogenic such as aspirin, NSAIDs, bile salts, cigarette smoking. Furthermore, ulcer patients impairment production within bulb, at rest response stimulation. These findings indicate pathogenesis peptic disease.