Impact of HIV Type 1 Subtype on Drug Resistance Mutations in Nigerian Patients Failing First-Line Therapy
作者： E. Idigbe , I. Adewole , W. Gashau , S. Meloni , A.D. Sarr
关键词: Logistic regression 、 Reverse transcriptase 、 Odds ratio 、 Resistance mutation 、 Drug resistance 、 Regimen 、 Virology 、 Biology 、 Multivariate analysis 、 Mutation
摘要: Abstract A diverse array of non-subtype B HIV-1 viruses circulates in Africa and dominates the global pandemic. It is important to understand how drug resistance mutations non-B subtypes may develop differently from patterns described subtype B. reverse transcriptase protease sequences 338 patients with treatment failure first-line ART regimens were evaluated. Multivariate logistic regression was used examine effect on each mutation controlling for regimen, time therapy, total mutations. The distribution included CRF02_AG (45.0%), G (37.9%), CRF06_cpx (4.4%), (3.6%), other or recombinant (9.2%). most common NRTI M184V (89.1%) thymidine analog (TAMs). NNRTI Y181C (49.7%), K103N (36.4%), G190A (26.3%), A98G (19.5%). analysis showed that less likely have M41L compared [adjusted odds ratio...
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