Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria.

摘要: Introduction: The HIV-1 epidemic in African countries is largely due to non-B subtypes. Patterns and frequency of antiretroviral drug resistance mutations observed these may differ from those the developed world, where subtype B predominates. Methods: were assayed among Nigerian patients with treatment failure on first-line therapy (plasma HIV RNA > 1000 copies/mL). Sequence analysis reverse transcriptase protease gene revealed viral subtype. Specific patterns clinical characteristics are described K65R mutation. Results: Since 2005, 338 evaluated. most prevalent subtypes CRF02_AG [152 (44.9%)] G [128 (37.9%)]. Three hundred seven (90.8%) had previously received stavudine and/or zidovudine + lamivudine efavirenz or nevirapine; 41 (12.1%) tenofovir (TDF). common nucleoside inhibitor M184V (301, 89.1%) K70R (91, 26.9%). mutation was present 37 (10.9%). Q151M (P < 0.05), K219R, T69del 0.01) more who not TDF. Conclusions: increasingly recognized a challenging finding subtypes, whether they have been exposed