The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research—Advantages and Current Limitations:
作者： Jan M. Spitsbergen , Michael L. Kent
DOI: 10.1080/01926230390174959
关键词: Biology 、 Toxicology 、 Genome 、 Disease 、 Danio 、 Developmental biology 、 Genomics 、 Molecular genetics 、 Pathology 、 Zebrafish 、 Gene
摘要: The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification of roles specific genes and signaling pathways in development. genome will be completely sequenced within next 1-2 years. Together with substantial historical database regarding basic developmental biology, toxicology, gene transfer, rich foundation molecular genetic genomic data makes a powerful clarifying mechanisms toxicity. In contrast to highly advanced knowledge base on genetics zebrafish, our infectious noninfectious diseases pathologic lesions lags far behind information available most other domestic mammalian avian species, particularly rodents. Currently, minimal are spontaneous neoplasm rates or aging any commonly used wild-type mutant lines zebrafish. Therefore, fully utilize potential as an animal understanding human development, disease, toxicology we must greatly advance pathology.
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