Exercise protects against high-fat diet-induced hypothalamic inflammation

摘要: Abstract Hypothalamic inflammation is a potentially important process in the pathogenesis of high-fat diet-induced metabolic disorders that has recently received significant attention. Microglia are macrophage-like cells central nervous system which activated by pro-inflammatory signals causing local production specific interleukins and cytokines, these turn may further promote systemic disease. Whether or how this microglial activation can be averted reversed unknown. Since running exercise improves health been found to neuronal survival as well recovery brain functions after injury, we hypothesized regular treadmill blunt effect western diet on hypothalamic inflammation. Using low-density lipoprotein receptor deficient (ldlr −/−) mice better reflect human lipid metabolism, first confirmed hypothalamus severely increased upon exposure high-fat, “western”, diet. Moderate, but regular, markedly decreased mice. Furthermore, observed decline was associated with an improvement glucose tolerance. Our findings support hypothesis suggest interventions avert reverse damage offer relevant potential obesity treatment prevention.