The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish
作者： Ruth A. Perez , Nils Rehmann , Sheila Crain , Patricia LeBlanc , Cheryl Craft
DOI: 10.1007/S00216-010-4161-2
关键词: Spectroscopy 、 Ampoule 、 Chromatography 、 Nuclear magnetic resonance spectroscopy 、 Anhydrous 、 Mass spectrometry 、 Methanol 、 Chemistry 、 Stock solution 、 Azaspiracid
摘要: The production and certification of a series azaspiracid (AZA) calibration solution reference materials is described. Azaspiracids were isolated from contaminated mussels, purified by preparative liquid chromatography dried under vacuum to the anhydrous form. purity was assessed chromatography–mass spectrometry nuclear magnetic resonance spectroscopy. final concentration each AZA in CD3OH stock determined quantitative NMR This then diluted very accurately degassed, high methanol 1.47 ± 0.08 μmol/L for CRM-AZA1, 1.52 0.05 CRM-AZA2, 1.37 0.13 CRM-AZA3. Aliquots dispensed into argon-filled glass ampoules, which immediately flame-sealed. solutions are suitable method development, validation, or mass instrumentation quality control shellfish monitoring programs.
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Johanna Fink-Gremmels, Eugenia Dogliotti, Jadwiga Gzyl, Jean-Pierre Cravedi, Philippe Verger, Diane Benford, Philippe Grandjean, Carlos Van Peteghem, Corrado Galli, Rolaf van Leeuwen, Antonio Mutti, Josef Schlatter, Peter Fürst, María Luisa Fernández-Cruz, Niklas Johansson, Alessandro Di Domenico, Gerhard Heinemeyer, Andrew Cockburn, Jan Alexander, Marine biotoxins in shellfish - Azaspiracid group 1 Scientific Opinion of the Panel on Contaminants in the Food chain ,(2008)
Urban Tillmann, Malte Elbrächter, Bernd Krock, Uwe John, Allan Cembella, Azadinium spinosum gen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins European Journal of Phycology. ,vol. 44, pp. 63- 79 ,(2009) , 10.1080/09670260802578534
Michael J. Twiner, James C. Ryan, Jeanine S. Morey, Kent J. Smith, Samar M. Hammad, Frances M. Van Dolah, Philipp Hess, Terry McMahon, Masayuki Satake, Takeshi Yasumoto, Gregory J. Doucette, Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid Genomics. ,vol. 91, pp. 289- 300 ,(2008) , 10.1016/J.YGENO.2007.10.015
Pearse McCarron, Håkan Emteborg, Philipp Hess, Freeze-drying for the stabilisation of shellfish toxins in mussel tissue (Mytilus edulis) reference materials Analytical and Bioanalytical Chemistry. ,vol. 387, pp. 2475- 2486 ,(2007) , 10.1007/S00216-006-1104-Z
Ana Braña Magdalena, Mary Lehane, Sophie Krys, Mariá Luisa Fernández, Ambrose Furey, Kevin J James, The first identification of azaspiracids in shellfish from France and Spain Toxicon. ,vol. 42, pp. 105- 108 ,(2003) , 10.1016/S0041-0101(03)00105-3
Pearse McCarron, Jane Kilcoyne, Christopher O. Miles, Philipp Hess, Formation of Azaspiracids-3, -4, -6, and -9 via decarboxylation of carboxyazaspiracid metabolites from shellfish. Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 160- 169 ,(2009) , 10.1021/JF8025138
Emiko Ito, Masayuki Satake, Katsuya Ofuji, Morihiro Higashi, Kenichi Harigaya, Terry McMahon, Takeshi Yasumoto, Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels. Toxicon. ,vol. 40, pp. 193- 203 ,(2002) , 10.1016/S0041-0101(01)00226-4
T. P. J. Linsinger, A. M. H. van der Veen, B. M. Gawlik, J. Pauwels, A. Lamberty, Planning and combining of isochronous stability studies of CRMs Accreditation and Quality Assurance. ,vol. 9, pp. 464- 472 ,(2004) , 10.1007/S00769-004-0818-X
Ambrose Furey, Cian Moroney, Ana Braña Magdalena, Maria José Fidalgo Saez, Mary Lehane, Kevin J. James, Geographical, temporal, and species variation of the polyether toxins, azaspiracids, in shellfish. Environmental Science & Technology. ,vol. 37, pp. 3078- 3084 ,(2003) , 10.1021/ES020246Z
Emiko Ito, Masayuki Satake, Katsuya Ofuji, Nobuyuki Kurita, Terry McMahon, Kevin James, Takeshi Yasumoto, Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon. ,vol. 38, pp. 917- 930 ,(2000) , 10.1016/S0041-0101(99)00203-2