Electrophysiology clarifies the megariddles of the mitochondrial permeability transition pore

摘要: After a brief review of the early history mitochondrial electrophysiology, contribution this approach to study permeability transition (MPT) is recapitulated. It has for example provided evidence dimeric nature MPT pore, allowed distinction between two levels control its activity, and underscored relevance redox events phenomenon. Single-channel recording provides means finally solve riddle biochemical entity underlying it by comparing characteristics pore with those channels formed candidate molecules or complexes. The possibility that may be protein import machinery inner membrane emphasized.