Extramedullary acute myelogenous leukemia

摘要: Extramedullary leukemia (EM AML), also known as myeloid sarcoma, is a rare manifestation of acute myelogenous and often accompanies bone marrow involvement. EM AML diagnosed based on H&E stains with ancillary studies including flow cytometry cytogenetics. Isolated misdiagnosed large cell lymphoma or other lymphoproliferative disorder. The clinical presentation dictated by the mass effect location tumor. optimal treatment remains unclear. High-dose chemotherapy, radiation, surgical resection, allogeneic stem transplantation are all modalities that can be incorporated into therapy AML. Cytarabine-based remission induction regimens have been most commonly used in upfront setting. There limited data about consolidation. Transplantation ideally offered for high risk disease relapsed In this manuscript, we will review recent literature AML, focusing proposing algorithm managing form leukemia. Further addressing stratification, role molecular genetic aberrations, strategies warranted.