Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease

摘要: BACKGROUND: Acute myeloid leukemia (AML) infrequently involves the central nervous system (CNS). This study was undertaken in patients with AML to determine whether cytogenetic findings predict CNS involvement. METHODS: The medical records of 1354 who were treated at The University Texas MD Anderson Cancer Center between January 2000 and December 2008 reviewed. Forty (3%) had involvement time presentation or disease recurrence, whom 37 conventional cytogenetics performed on bone marrow aspirate material. Demographics, treatment, status last follow-up collected. RESULTS: Eleven (30%) a diploid karyotype, 14 (38%) complex cytogenetics. Only 5 40 diagnosis, remaining relapse. Patients developed younger (P = .019), higher white blood cell (WBC) count diagnosis .001), lactate dehydrogenase level (LDH) levels < .0001), percentages peripheral blast cells .024) compared rest population. In addition, rates chromosome 16 inversion 11 abnormality .005), trisomy 8 .02) tendency toward .2) control group (patients no involvement). CONCLUSIONS: Patients often LDH WBC counts they presented abnormalities. current indicated that overall survival is poor. 2012;. © 2011 American Society.